A type of anticancer drug, the farnesyltransferase inhibitors (FTIs), has been proposed, but their use has been mostly limited to animal models. A Phase II clinical trial using the FTI lonafarnib began in May 2007. In studies on the cells another anti-cancer drug, rapamycin, caused removal of progerin from the nuclear membrane through autophagy. It has been proved that pravastatin and zoledronate are effective drugs when it comes to the blocking of farnesyl group production. However, it is important to remember that no treatment is able to cure progeria. Continue reading
Tag Archives: aging
How Aging Affects Our Mouth
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Aging is a normal life process, which is subtle and is characterized by individual variation in onset and rate of decline. The basis of this process lies in changes in various macromolecules (from D.N.A. to membrane proteins) which primarily lead to alteration the form of function of a tissue or organ as a result of biological activity associated with a minor disturbance of normal cellular turnover. Continue reading